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April 11, 2024

Episode 125 – How Do Nerve Growth Factor Inhibitors Transform Veterinary Pain Management?

This episode is a snippet from the late 2023 Veterinary Pain Management Workshop hosted by IVDI, which offers a deep dive into nerve growth factor inhibitors, focuses on the cutting-edge therapeutic agents, Salencia for cats and Librella for dogs, addressing their mechanism and impact on pain management. Dr. Mark Epstein, a renowned pain management expert, shares insights from a 2023 workshop, breaking down complex mechanisms and their practical applications in clinical settings.

Main Talking Points:

  • Introduction to Nerve Growth Factor (NGF) and its inhibitors.
  • The biology and impact of NGF on pain pathways.
  • Clinical use and observations with Silencia in cats and Labrella in dogs.
  • Potential concerns and ongoing questions about NGF inhibitors.
  • Co-administration with NSAIDs and its implications.

Interesting Quotes:

  • “NGF is largely responsible for amplifying neurogenic inflammation, making it a prime target for therapeutic intervention.”
  • “Silencia and Labrella offer significant improvements in mobility and quality of life for cats and dogs suffering from osteoarthritis.”


  • 0:00 – Introduction to the episode
  • 1:30 – Speaker introduction: Dr. Mark Epstein
  • 2:00 – Overview of nerve growth factor inhibitors
  • 4:00 – The science behind NGF and pain management
  • 6:00 – Clinical observations with Silencia and Labrella
  • 8:00 – Addressing concerns and unanswered questions
  • 9:30 – Discussion on co-administration with NSAIDs

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This episode sheds light on the pivotal role of nerve growth factor inhibitors in managing chronic pain in pets. Dr. Mark Epstein’s expertise offers a comprehensive understanding of how these inhibitors work, their clinical benefits, and the nuanced considerations in their application.